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Nucleic Acid Delivery across Biological Barriers
2021
Yakugaku zasshi
One of the current critical issues in nucleic acid delivery is the efficient mRNA delivery into target cells, directed toward clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) genome editing. To this end, we have developed a variety of cationic polyaspartamide derivatives with varying side chain structures because they can form nanocomplexes, termed polyplexes, with mRNA through electrostatic interactions. Interestingly, the delivery functions were
doi:10.1248/yakushi.20-00219-2
pmid:33952744
fatcat:ejcrbnaxanclzeu4egmr4bwmvm