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Evidence That the Peptidylprolyl Isomerase Domain of the hsp90-binding Immunophilin FKBP52 Is Involved in Both Dynein Interaction and Glucocorticoid Receptor Movement to the Nucleus
2001
Journal of Biological Chemistry
We have previously shown that immunoadsorption of the FKBP52 immunophilin component of steroid receptor⅐hsp90 heterocomplexes is accompanied by coadsorption of cytoplasmic dynein, a motor protein involved in retrograde transport of vesicles toward the nucleus. Coimmunoadsorption of dynein is competed by an expressed fragment of FKBP52 comprising its peptidylprolyl isomerase (PPIase) domain (Silverstein, A. M.,
doi:10.1074/jbc.m010809200
pmid:11278753
fatcat:xz73lpmfrzcunnqglsakcf4fqu