Treatment of patients with tumors of the maxillofacial region is a complex multi-step process. The type and volume of treatment were determined by the prevalence of cancer process. The plan of complex treatment of this group of patients was made individually but depending on the morphological variant, clinical and anatomic characteristics, dental status, carcinogenic factors and stage of disease. For dynamic observation of the stages of treatment it is advisable to use biomarkers, through which it is possible to monitor the resulting effect.