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Terpenoids from the Marine-Derived Fungus Aspergillus fumigatus YK-7
2015
Molecules
Preserved Fulltext
Two new β-bergamotane sesquiterpenoids, E-β-trans-5,8,11-trihydroxybergamot-9-ene (1) and β-trans-2β,5,15-trihydroxybergamot-10-ene (2), were isolated from the marine-derived fungus Aspergillus fumigatus YK-7, along with three known terpenoids 3-5. Their structures were determined by spectroscopic methods (1D and 2D NMR, HR-ESI-MS). Antiproliferative effects on human leukemic monocyte lymphoma U937 and human prostate cancer PC-3 cell lines were measured in vitro. Compound 4 exhibited potent
doi:10.3390/molecules21010031
pmid:26729074
fatcat:6drf4uravjejjaz5mqvkobmkiq