Terpenoids from the Marine-Derived Fungus Aspergillus fumigatus YK-7

Yu Wang, Da-Hong Li, Zhan-Lin Li, Yan-Jun Sun, Hui-Ming Hua, Tao Liu, Jiao Bai
2015 Molecules  
Two new β-bergamotane sesquiterpenoids, E-β-trans-5,8,11-trihydroxybergamot-9-ene (1) and β-trans-2β,5,15-trihydroxybergamot-10-ene (2), were isolated from the marine-derived fungus Aspergillus fumigatus YK-7, along with three known terpenoids 3-5. Their structures were determined by spectroscopic methods (1D and 2D NMR, HR-ESI-MS). Antiproliferative effects on human leukemic monocyte lymphoma U937 and human prostate cancer PC-3 cell lines were measured in vitro. Compound 4 exhibited potent
more » ... vity against the U937 cell line with an IC 50 value of 4.2 µM.
doi:10.3390/molecules21010031 pmid:26729074 fatcat:6drf4uravjejjaz5mqvkobmkiq