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eQTL Epistasis – Challenges and Computational Approaches
2013
Frontiers in Genetics
The determination of expression quantitative trait loci (eQTL) epistasis - a form of functional interaction between genetic loci that affect gene expression - is an important step toward the thorough understanding of gene regulation. Since gene expression has emerged as an "intermediate" molecular phenotype eQTL epistasis might help to explain the relationship between genotype and higher level organismal phenotypes such as diseases. A characteristic feature of eQTL analysis is the big number of
doi:10.3389/fgene.2013.00051
pmid:23755066
pmcid:PMC3668133
fatcat:3c75cyzoqzgtvmjbiwbcgd2f3q