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Shedding of culturable virus, seroconversion, and 6-month follow-up antibody responses in the first 14 confirmed cases of COVID-19 in the United States

Marie E Killerby, Mohammad Ata Ur Rasheed, Azaibi Tamin, Jennifer L Harcourt, Glen R Abedi, Xiaoyan Lu, Stephanie Kujawski, Melisa M Shah, Hannah L Kirking, Jeremy A W Gold, Phillip P Salvatore, Melissa M Coughlin (+9 others)
2021 Journal of Infectious Diseases  

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https://web.archive.org/web/20210312022522/https://watermark.silverchair.com/jiab125.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAArYwggKyBgkqhkiG9w0BBwagggKjMIICnwIBADCCApgGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMncdqhAEz4BYMym4LAgEQgIICaWLkWv-yivi0kZTAESzWT_HmI6MEJF1mpWNP2ePFRQRtRI_uA8F01Yg9pfl8zcVngQlR9_bJR4AfAhnUcw9OOni5dbRMZNUbEwQlx5FrTcCLSwVUznwIBS2xxlpUpsp3mDerKhgx0uyn7lW40Qku5lsSY12ozkM5cSNk2EesSiWuwjsteCFOEMig06efz3X0K6Ed0xbZwZ8Gir48CwY-Jk1TK1r90EbEmiGchkbjQI88k8V8FTqpR1SllXYeVAeVUNxDU2j_GeH7DJ6ZqTcOdVLUP77Q3XuAOc7vH5qJAxQ3wJd5XHX-Y5ZdkwkueJ6TOiWV5DiXbzeyHGkL1gbq0XO4Wy1VyBX0eHXbICpYWSqKMcE1_5Z5_TxYHJVUGcth0Mal1keZ-siEz_JfyjpmLy0TA3zNL7P6ukIkZt_pTx9A2wURNscpelFB9hgwa1oXyvlnTrpXJDOjKLkwLnL7vtpzzo4k0Qy9e1ISRSQiKybsuSGOLB0PGs6fFUUALkagU0bdHDXpugLhQC_XXvfOWZFCeJh7xD-M9az10foX6JziiwW64yXrk9RoalJKA4Dp-t7go83SbCZDQANUtKJ6XbMuJYg3InfLw08W7j3mY1EjX-WShiQm2nWMtpPUdWL6inxGN-MfFTPFZuG07MQZKQyj-GrUXJ6XKokqOxZrAfItuFFcbqc2s2Q66TbKWnbvtwjUPfenBeG8EF0oCxVC6BsZ9XNbufj2Doh46hAsZf2h0GhDSmlDVJtmgPUiuQDWpDLizAXvl0Usgb_f7KG1gSb0R72ED_3C6h1U2pqMyZeQOmoirvf5HC9V

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We aimed to characterize presence of culturable virus in clinical specimens during acute illness, and antibody kinetics up to six months post-onset, among 14 early US COVID-19 patients. We isolated viable SARS-CoV-2 from rRT-PCR-positive respiratory specimens collected during days 0-8 post-onset, but not after. All 13 patients with two or more serum specimens developed anti-spike antibodies; 12 developed detectable neutralizing antibodies. We did not isolate virus after detection of
more » ... antibodies. Eight participants provided serum at six months post-onset; all retained detectable anti-spike IgG, and half had detectable neutralizing antibodies. Two participants reported not feeling fully recovered at six months.
doi:10.1093/infdis/jiab125 pmid:33693830 fatcat:qa463ghjqvg4xlohc233obzizy
Citation

Marie E Killerby, Mohammad Ata Ur Rasheed, Azaibi Tamin, Jennifer L Harcourt, Glen R Abedi, Xiaoyan Lu, Stephanie Kujawski, Melisa M Shah, Hannah L Kirking, Jeremy A W Gold, Phillip P Salvatore, Melissa M Coughlin, Brett Whitaker, Jacqueline E Tate, John T Watson, Stephen Lindstrom, Aron J Hall, Alicia M Fry, Susan I Gerber, Claire M Midgley, Natalie J Thornburg. "Shedding of culturable virus, seroconversion, and 6-month follow-up antibody responses in the first 14 confirmed cases of COVID-19 in the United States." Journal of Infectious Diseases 224.5 (2021)