Shedding of culturable virus, seroconversion, and 6-month follow-up antibody responses in the first 14 confirmed cases of COVID-19 in the United States

Marie E Killerby, Mohammad Ata Ur Rasheed, Azaibi Tamin, Jennifer L Harcourt, Glen R Abedi, Xiaoyan Lu, Stephanie Kujawski, Melisa M Shah, Hannah L Kirking, Jeremy A W Gold, Phillip P Salvatore, Melissa M Coughlin (+9 others)
2021 Journal of Infectious Diseases  
We aimed to characterize presence of culturable virus in clinical specimens during acute illness, and antibody kinetics up to six months post-onset, among 14 early US COVID-19 patients. We isolated viable SARS-CoV-2 from rRT-PCR-positive respiratory specimens collected during days 0-8 post-onset, but not after. All 13 patients with two or more serum specimens developed anti-spike antibodies; 12 developed detectable neutralizing antibodies. We did not isolate virus after detection of
more » ... antibodies. Eight participants provided serum at six months post-onset; all retained detectable anti-spike IgG, and half had detectable neutralizing antibodies. Two participants reported not feeling fully recovered at six months.
doi:10.1093/infdis/jiab125 pmid:33693830 fatcat:qa463ghjqvg4xlohc233obzizy