Renalase in hypertension and kidney disease

Gary V. Desir, Aldo J. Peixoto
2013 Nephrology, Dialysis and Transplantation  
A B S T R AC T Renalase, a recently discovered flavoprotein, which is strongly expressed in the kidney and heart, effectively metabolizes catecholamines. It was discovered during the search to identify proteins secreted by the kidney that could help explain the high incidence of cardiovascular disease in patients with chronic kidney disease. Recent advances have led to more detailed knowledge of its biology, structure, enzymatic activity, mechanisms of action, associations with human disease
more » ... tes and potential therapeutic value. In this study, we review these
doi:10.1093/ndt/gft083 pmid:24137013 fatcat:xws4n57lljctffp6ihdydtax2i