Molecular epidemiology of human papillomavirus in pregnant women in Burkina Faso

Koudpoko Madeleine Kabre, Djénéba Ouermi, Théodora Mahoukèdè Zohoncon, Fatié Porzé Wilfried Traore, Ouamini Pulchérie De Prisca Gnoumou, Rogomenoma Alice Ouedraogo, Albert Théophane Yonli, Prosper Bado, Paul Ouedraogo, Teega-Wendé Clarisse Ouedraogo, Tampoula Edwige Yelemkoure, Punya Akouélé Kuassi-Kpede (+3 others)
Genital human papillomavirus (HPV) infection is widespread among sexually active individuals. Several factors may contribute to increased risk of infection in pregnant women. The objective of this study was to determine the high-risk (HR-HPV) and low-risk (LR-HPV) oncogenic HPV genotypes among pregnant women in Ouagadougou. In this study, 100 endocervical samples were collected using a sterile swab on the sterile examination glove used during vaginal examination in pregnant women. DNA from each
more » ... sample was amplified by PCR followed by hybridization using the HPV Direct Flow Chips kit detecting 36 HPV genotypes. Twenty-three percent (23%) of pregnant women had HPV infection. Of the 36 genotypes tested, 29 genotypes had been identified with a predominance of HPV 52 (10.34%), HPV 35 (6.89%), and HPV 82 (6.89%) for high risk and HPV 43 (10.34%), HPV 44/55 (6.90%), and HPV 62/81 (6.89%) for low risk. HPV is common among pregnant women in Burkina Faso. However, the available vaccines do not cover the frequent genotypes found in this study. HPV could therefore constitute a threat for pregnant women and a risk of infection for the newborn.
doi:10.1515/bmc-2022-0026 pmid:36727673 fatcat:ncahhjyu2fdsxnr45jqohexzoq