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Effect of gliclazide on cardiovascular risk factors involved in split-dose streptozotocin induced neonatal rat model: a chronic study
International Journal of Basic & Clinical Pharmacology
The present study aimed at evaluating the effect of gliclazide on cardiovascular risk factors involved in type 2 diabetes mellitus using n-STZ rat model on a long term basis. Methods: The diabetic model was developed using a split dose of streptozotocin (50 mg/kg) intraperitoneally on 2 nd and 3 rd postnatal days. The diabetic rats were treated orally with gliclazide suspension at the dose of 10 mg/kg for 90 days. Cardiovascular risk factors such as systolic blood pressure, heart rate, lipiddoi:10.5455/2319-2003.ijbcp003612 fatcat:cnb3dfqotvfuffabxj3vd667ja