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Functionalized Folic Acid with Chitosan and PAMAM Dendrimers for Delivery of DNA and RNA
2021
Journal of Nanotechnology and Nanomaterials
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In this review, we explore the potential applications of functionalized folic acid-polymer nanoparticles in nucleic acids delivery. Folic acid-chitosan (carbohydrates) and folic acid-PAMAM (dendrimers) of different polymer sizes were used to conjugate with DNA and tRNA in vitro. Thermodynamic analysis showed that conjugation of DNA and tRNA to nanoparticles occurred via hydrophilic, hydrophobic, H-bonding and van der Waals contacts. Major alterations of DNA and RNA morphology occurred by
doi:10.33696/nanotechnol.2.019
fatcat:g5e5hrub6jhxtfndjog6stxn7y