Selective transacylation reactions on 4-aryl-3,4-dihydropyrimidin-2-ones and nucleosides mediated by novel lipases

Poonam, Ashok K. Prasad, Chandrani Mukherjee, Gaurav Shakya, Gautam K. Meghwanshi, Jesper Wengel, Rajendra K. Saxena, Virinder S. Parmar
2005 Pure and Applied Chemistry  
Different (±)-4-(3/4-acetoxyaryl)-5-ethoxycarbonyl-6-methyl-3,4-dihydropyrimidin-2-ones have been synthesized and subjected to enantioselective deacetylation reactions mediated by different lipases in organic media. Novozyme 435 in tetrahydrofuran:diisopropyl ether was found to be the catalyst of choice for efficient enantioselective deacetylation of dihydropyrimidinones under study. Further, we discovered that lipase isolated from
doi:10.1351/pac200577010237 fatcat:3hkuxdpz4bccboq3onctlf7suu