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Frequent genetic alterations discovered in FGFRs and evidence implicating some as drivers in diverse tumors has been accompanied by rapid progress in targeting FGFRs for anticancer treatments. Wider assessment of the impact of genetic changes on the activation state and drug responses is needed to better link the genomic data and treatment options. We here apply a direct comparative and comprehensive analysis of FGFR3 kinase domain variants representing the diversity of pointmutations reporteddoi:10.18632/oncotarget.8132 pmid:26992226 pmcid:PMC5029699 fatcat:lzier7rbbbginoo76xdxmqsvvy