SCRUTINY OF VARIOUS LEAF EXTRACTS OF CARALLUM FIMBRIATA FOR ANTIOXIDANT ACTIVITY IN WISTAR RATS
International Research Journal of Pharmacy
Caralluma fimbriata is an edible succulent cactus that belongs to Asclepiadaceae family which is called as famine food. Native Indian diets have comprised these edible wild succulent cacti over many centuries. It has found to be useful for remedy of diabetes, obesity and heart problems. Antioxidant activity of aqueous and ethanol extracts of Caralluma fimbriata was evaluated by reckoning of lipid peroxide level in brain and liver homogenate of rats tissues and appraising of hydroxyl radical
... ydroxyl radical scavenging through deoxy ribose assay. The results obtained from assessment manifested leaves of Caralluma fimbriata possessed substantial antioxidant activity by declining in level of lipid peroxidation and hydroxyl radical activity. Fifty percentage of inhibition concentration was perceived to be 630 μg/ml and 487 μg/ml for aqueous and ethanol extracts of Caralluma fimbriata respectively for lipid peroxidation in brain homogenates. IC50 values of aqueous and ethanol extracts of Caralluma fimbriata was found to be 800 μg/ml and 781 μg/ml respectively for lipid peroxidation assay in liver homogenates. IC50 values of aqueous and ethanol extracts of Caralluma fimbriata was found to be 746 μg/ml and 662 μg/ml respectively for hydroxyl radical scavenging activity. The current research on Caralluma fimbriata extracts exhibits prospective antioxidant activity so it can be considerable beneficial for remedy of Alzheimer's disease, Parkinson disease and cancer as nutritional supplements.