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Early Critical Phase Transitions of Pericentromere-Associated Domains in MCF-7 Breast Cancer Cells Committed to Differentiation by Heregulin
[post]
2020
unpublished
Finding out how cells with the same genome change fates in differentiation commitment is a challenge of biology. We used MCF-7 breast cancer cells treated with the ErbB2 ligand heregulin (HRG), which induces differentiation, to address if and how the constitutive pericentromere-associated domains (PADs) may be involved in this process. PAD-specific repressive heterochromatin (H3K9me3) and active euchromatin (H3K4me3) marking, centromere (CENPA) labelling, qPCR, acridine-orange-DNA structural
doi:10.20944/preprints202005.0248.v1
fatcat:34tvzwvtmjekvnjmnxfu4bl7rq