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Novel cell death program leads to neutrophil extracellular traps
Journal of Experimental Medicine
N eutrophil extracellular traps (NETs) are extracellular structures composed of chromatin and granule proteins that bind and kill microorganisms. We show that upon stimulation, the nuclei of neutrophils lose their shape, and the eu-and heterochromatin homogenize. Later, the nuclear envelope and the granule membranes disintegrate, allowing the mixing of NET components. Finally, the NETs are released as the cell membrane breaks. This cell death process is distinct from apoptosis and necrosis anddoi:10.1084/jem2041oia2 fatcat:3gymi6ci6vcbhiep2pqoqqqfji