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Functional Coassembly of KCNQ4 with KCNE-ß- Subunits in Xenopus Oocytes
Cellular Physiology and Biochemistry
The KCNQ gene family comprises voltage-gated potassium channels expressed in epithelial tissues (KCNQ1, KCNQ5), inner ear structures (KCNQ1, KCNQ4) and the brain (KCNQ2-5). KCNQ4 is expressed in inner and outer hair cells of the inner ear where it influences electrical excitability and cell survival. Accordingly, loss of function mutations of the KCNQ4 gene cause hearing loss in humans and functional k.o.-mice show progressive degeneration of outer hair cells (OHCs). However, characteristicdoi:10.1159/000095158 pmid:16914890 fatcat:budontcdn5ghfibnaxgy4bs6ty