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A b s t r a c t The activated protein C resistance (APCR) assay is the test of choice to screen for factor V Leiden. We evaluated the effect of lupus anticoagulant on the baseline clotting time of the second-generation APCR assay with plasma samples from 54 patients to determine whether a falsely low APCR ratio could be predicted. We also assessed whether a modification of the assay could make it more reliable in the presence of strong lupus anticoagulants. Of 54 plasma samples, 5 yielded adoi:10.1309/1gn6ntm7bqap8vkx pmid:12520699 fatcat:6lxucrvegnhpxnmuxpre4uhrpe