A correlation between HCV infection and metabolic disorders, such as dyslipidemia and type II diabetes, has emerged. High serum cholesterol and LDL levels were demonstrated to enhance the probability of sustained viral response (SVR) of chronic hepatitis C. Conversely, insulin resistance impairs the SVR rates. Since HIV infection and antiretroviral therapies may also affect metabolic parameters, we investigated the influence of baseline glucose and lipid values on the outcome of HCV treatment in HIV-1 infected subjects.