Microglial NLRP3 inflammasome activates neurotoxic astrocytes in depression-like mice

Shanshan Li, Yinquan Fang, Yihe Zhang, Mengmeng Song, Xilin Zhang, Xiao Ding, Hang Yao, Miaomiao Chen, Yiming Sun, Jianhua Ding, Qin Wang, Ming Lu (+2 others)
2022 Cell Reports  
Highlights d Neurotoxic A1-like astrocytes are enhanced in the CMS depression mouse model d NLRP3 inflammasome in microglia but not in astrocytes induces A1-like astrocytes d NLRP3 inflammasome activates microglia and promotes A1 cocktail secretion d NF-kB and caspase-1 pathways are involved in NLRP3induced astrocyte reactivity
doi:10.1016/j.celrep.2022.111532 fatcat:2jfaqxcq3bdn5hewyv3w2diam4