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Microglial NLRP3 inflammasome activates neurotoxic astrocytes in depression-like mice
Highlights d Neurotoxic A1-like astrocytes are enhanced in the CMS depression mouse model d NLRP3 inflammasome in microglia but not in astrocytes induces A1-like astrocytes d NLRP3 inflammasome activates microglia and promotes A1 cocktail secretion d NF-kB and caspase-1 pathways are involved in NLRP3induced astrocyte reactivitydoi:10.1016/j.celrep.2022.111532 fatcat:2jfaqxcq3bdn5hewyv3w2diam4