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SYK Is Upstream of Phosphoinositide 3-Kinase in B Cell Receptor Signaling
1999
Journal of Biological Chemistry
We have recently demonstrated that the D3-phosphoinositide phosphatidylinositol 3,4,5-trisphosphate (Pt-dIns-3,4,5-P 3 ) is critical for producing sustained calcium signals through its role in promoting the function of TEC family tyrosine kinases such as Bruton's tyrosine kinase. Although PtdIns-3,4,5-P 3 can potentially be synthesized by any of several types of phosphoinositide 3-kinases (PI3Ks), B cell receptor (BCR)-induced PtdIns-3,4,5-P 3 production is thought to occur primarily through
doi:10.1074/jbc.274.46.32662
pmid:10551821
fatcat:jf2x25iqk5hgpasb4bzolt2y3i