A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2017; you can also visit the original URL.
The file type is
We determined whether chronic endothelin-1 (ET-1) treatment could lead to in vivo insulin resistance. Like insulin, ET-1 acutely stimulated glucose transport in isolated soleus muscle strips of WKY rats. ET-1 pretreatment (1 h) decreased insulin-stimulated glucose transport in muscle strips (؊23%). Both ET-1-mediated effects were generated through ET A receptors, because a specific ET A receptor antagonist (BQ610) blocked these effects of ET-1. Osmotic minipumps were used to treat normal ratsdoi:10.2337/diabetes.52.8.1904 pmid:12882904 fatcat:z3k7g25v2nexzmgbuetf64bje4