researchers attribute obesity to an independent risk factor for perioperative complications of off-pump coronary artery bypass grafting (off-pump CABG). AIM. To conduct a comparative analysis of the early postoperative complications of off-pump CABG in obesity patients with with various types of anesthetic benefits. MATERIALS AND METHODS. A randomized study of the results of surgical treatment was carried out in obesity patients with coronary heart disease performing pump CABG. The study

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... d 197 patients. The study group (n = 98) included patients who underwent combined anesthesia (with thoracic epidural analgesia (TEA)), and patients in the control group (n = 99) underwent total intravenous anesthesia (with opioids). RESULTS. The use of combined anesthesia (with TEA) in patients with obesity significantly reduced the risk of developing new onset of renal dysfunction (p = 0.0180), respiratory complications (p = 0.0177), atrial and ventricular arrhythmias (p = 0.0029). We were less likely to diagnose other complications in patients of the study group, compared with patients in the control group: acute coronary syndrome (1.0% versus 3.0%, p = 0.3173), multiple organ failure syndrome (1.0% versus 3.0%, p = 0.3173), local infectious complications (1.0% versus 6.1%, p = 0.0561). An uncomplicated early postoperative period was observed in 89.8% of patients in the study group and in 52.5% of patients in the control group (p = 0.0000). CONCLUSION. The use of combined anesthesia (with TEA) for off-pump CABG in patients with obesity reduces the risk of early postoperative complications, duration of hospitalization and stay in an intensive care unit. K E Y w O R D S -off-pump coronary artery bypass grafting, prevention of complication, obesity, thoracic epidural analgesia.