Keywords: Inappropriate prescribing older adults nursing home pharmacoepidemiology a b s t r a c t Importance: As older adults living in nursing homes are at a high risk of adverse drug-related events, medications with a poor benefit/risk ratio or with a safer alternative should be avoided. Objectives: To systematically evaluate the prevalence of potentially inappropriate medication use in nursing home residents. Evidence review: We searched in PubMed and EMBASE databases (1990e2015) for

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... reporting the prevalence of potentially inappropriate medication use in people 60 years of age living in nursing homes. The risk of bias was assessed with an adapted version of the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist. Findings: A total of 91 articles were assessed for eligibility, and 48 met our inclusion criteria. These articles reported the findings from 43 distinct studies, of which 26 presented point prevalence estimates of potentially inappropriate medication use (227,534 nursing home residents). The overall weighted point prevalence of potentially inappropriate medication use in nursing homes was 43.2% [95% confidence interval (CI) 37.3%e49.1%], increasing from 30.3% in studies conducted during 1990e1999 to 49.8% in studies conducted after 2005 (P < .001). Point prevalence estimates reported in European countries were found to be higher (49.0%, 95% CI 42.5e55.5) than those reported in North America (26.8%, 95% CI 16.5e37.1) or in other countries (29.8%, 95% CI 19.3e40.3). In addition, 18 studies accounting for 326,562 nursing home residents presented 20 distinct period prevalence estimates ranging from 2.3% to 50.3%. The total number of prescribed medications was consistently reported as the main driving factor for potentially inappropriate medications use. Conclusions and relevance: This systematic review shows that almost one-half of nursing home residents are exposed to potentially inappropriate medications and suggests an increase prevalence over time. Effective interventions to optimize drug prescribing in nursing home facilities are, therefore, needed.