Multiple primary tumors are rare but their incidence is increasing. We aimed to present a case report about a patient with synchronous gastric and colon cancer, who has undergone a simultaneous resection of both tumors and developed (preventable) postoperative complications. A 69-year-old male patient, who was diagnosed with severe acute respiratory syndrome coronavirus-2019 infection 3 months ahead of his admission, presented to the Trakya University due to gastric bleeding. Colonoscopy and

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... phago gastro duodenoscopy were performed upon complaints. The patient was diagnosed with synchronous gastric and colon adenocarcinoma. Total gastrectomy, left hemicolectomy, and Roux-en-Y esophagojejunostomy were performed simultaneously. Although there were no postoperative surgical complications, the patient developed a pulmonary embolism. In the presence of a gastrointestinal tumor, the synchronous or metachronous tumor should also be evaluated. The most appropriate surgical treatment is simultaneous resection of both tumors. Physicians should also consider the risk of a pulmonary embolism that may develop after these major surgeries.