In this study, we described the biodegradation process of cellulose based on the Boltzmann distribution derived from autocatalytic kinetics. From the autocatalytic model (MAC) we concluded that the molecular weight, temperature, and the interaction parameter (𝑥) (type of polymer and biodegrading agent) are the major factors governing the phenomenon of biodegradation. The modeled results and the experimental results, according to the ASTM D5511 protocol, present a good correlation.