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Effects of the novel antiarrhythmic agent azimilide on experimental atrial fibrillation and atrial electrophysiologic properties
Objectives: This study was designed to evaluate how the atrial electrophysiological and antiarrhythmic effects of azimilide compare Ž . with those of the specific rapid delayed rectifier I blocker dofetilide. Background: Azimilide, a new class III drug, was initially Kr Ž . believed to be a highly selective blocker of the slow delayed rectifier I , but recent studies suggest that azimilide potently blocks I . Ks Kr Thus, it has been suggested that azimilide's in vivo effects may simply be duedoi:10.1016/s0008-6363(97)00252-6 pmid:9659446 fatcat:t5oqccofgzfbbnvzikhvw5ild4