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Halohydrin dehalogenases are promiscuous biocatalysts, which enable asymmetric ring opening reactions of epoxides with various anionic nucleophiles. However, despite the increasing interest in such asymmetric transformations, the substrate scope of G-type halohydrin dehalogenases toward cyclic epoxides has remained largely unexplored, even though this family is the only one known to display activity with these sterically demanding substrates. Herein, we report on the exploration of thedoi:10.26434/chemrxiv-2022-jl3gd fatcat:4tmlquew4fdttn6o5tgicdzaom