A case of malignant fibrous histiocytoma (MFH)
Myxoid variant of malignant fibrous histiocyioma(MFH)の1例 malignant peripheral nerve sheath tumor(MPNST)との鑑別が問題となった1例

Toshiaki YANAGI, Toshihiro SATO, Susumu TAKAYASU, Yuji ASADA, Sotaro KURATA, Masao CHUJO, Takashi MIURA, Seiji YOSHIDA, Shigeo YOKOYAMA
2000 Skin Cancer  
An 84-year-old woman presented with two large tumors on her chest and back, which had been operated twice. The tumor at the first operation was mainly composed of loosely arranged spindle cells with little atypicality and necrosis, mostly in myxomatous ground substance. At the later stage, the tumor cells showed obvious atypicality, including multinucleated giant cells, and were partly arranged in a storiform pattern. Mitotic figures were rarelly observed. Our tentative diagnosis was malignant
more » ... eripheral nerve sheath tumor. However, neither S-100 protein nor NSE was positive throughout the course. Therefore, we finally diagnosed her condition as myxoid variant of malignant fibrous histiocytoma. She died of local recurrence and distant metastasis to muscle, lung and liver. [Skin Cancer (Japan) 2000; 15: 39-43]
doi:10.5227/skincancer.15.39 fatcat:gpmlwvzqp5ap7bpgdio42jdxfq