Distinct Signaling Pathways Mediate Touch and Osmosensory Responses in a Polymodal Sensory Neuron

Anne C. Hart, Jamie Kass, Jonathan E. Shapiro, Joshua M. Kaplan
1999 Journal of Neuroscience  
The Caenorhabditis elegans ASH sensory neurons mediate responses to nose touch, hyperosmolarity, and volatile repellent chemicals. We show here that distinct signaling pathways mediate the responses to touch and hyperosmolarity. ASH neurons distinguish between these stimuli because habituation to nose touch has no effect on the response to high osmolarity or volatile chemicals (1-octanol). Mutations in osm-10 eliminate the response to hyperosmolarity but have no effect on responses to nose
more » ... ponses to nose touch or to volatile repellents. OSM-10 is a novel cytosolic protein expressed in ASH and three other classes of sensory neurons. Mutations in two other osmosensory-defective genes, eos-1 and eos-2, interact genetically with osm-10. Our analysis suggests that nose touch sensitivity and osmosensation occur via distinct signaling pathways in ASH and that OSM-10 is required for osmosensory signaling.
doi:10.1523/jneurosci.19-06-01952.1999 pmid:10066248 fatcat:yjtb532n4bghhbun67gfbvrwoi