A significant proportion of acute stroke patients suffer neurological deterioration during the first few days of recovery. Aim: To explore the frequency, clinical characteristics, and consequences of early neurological deterioration during the acute recovery period. Methods: We assessed all consecutive patients admitted to a University hospital with suspected stroke. We recorded the following on admission: baseline characteristics, physiological parameters and laboratory results. On day 5 we

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... orded occurrence of complications, and functional outcome. Early neurological deterioration was defined as an increase in National Institute of Health Stroke Score (NIHSS) by two or more points (or stroke-related death) between admission and day 5. Results: We recruited 188 stroke patients, of whom 36 (19%) suffered early neurological deterioration. Patients with early neurological deterioration were significantly more likely to: (i) arrive at the hospital earlier (median 2.25 vs. 7.2 h, p ¼ 0.015); (ii) have a history of atrial fibrillation (33% vs. 16%, p ¼ 0.039); (iii) be current non-smokers (24% vs. 11%, p ¼ 0.041); (iv) have a severe stroke-more total anterior circulation strokes (67% vs. 26%, p < 0.001) and worse NIHSS and GCS scores; (v) have intracerebral haemorrhage (22% vs. 7%, p ¼ 0.011); (vi) have higher serum urea (mean 7.8 vs. 6.5 mmol/l, p ¼ 0.035) and leukocyte count (mean 12.6 vs. 9.7 Â 10 9 /l, p ¼ 0.044); and (vi) die in hospital (44% vs. 10%, OR 12.8, 95%CI 3.8-43.1, p < 0.001). Discussion: Early neurological deterioration is a frequent and important complication in acute stroke, with a poor short-term prognosis. Effective treatment strategies are urgently needed to reduce its occurrence and impact on recovery.