Myocardial Injury Biomarkers and Cardiac Complications Associated with Mortality in Patients with COVID-19
Biomarcadores de Lesão Miocárdica e Complicações Cardíacas Associadas à Mortalidade em Pacientes com COVID-19

Paulo Ricardo Martins-Filho, José Augusto Soares Barreto-Filho, Victor Santana Santos
<span title="2020-08-28">2020</span> <i title="GN1 Genesis Network"> <a target="_blank" rel="noopener" href="" style="color: black;">Arquivos Brasileiros de Cardiologia</a> </i> &nbsp;
SARS-CoV-2 is an emerging RNA virus associated with a severe acute respiratory disease known as COVID-19. Although COVID-19 is predominantly a pulmonary disease, some patients have severe cardiovascular damage. We performed a quantitative evidence synthesis of clinical data, myocardial injury biomarkers, and cardiac complications associated with in-hospital death in patients with COVID-19. We searched the databases PubMed, Embase, and Google Scholar to identify studies comparing clinical data,
more &raquo; ... yocardial injury biomarkers, and cardiac complications between non-survivors and survivors of COVID-19. Effect sizes were reported as mean difference or standardized mean difference for continuous variables and risk ratio for dichotomous variables with 95% confidence intervals. A random effects model was used to pool the results. Six retrospective studies reporting data from 1,141 patients (832 survivors and 309 non-survivors) were included. We found that underlying cardiovascular conditions; elevation of high-sensitivity cardiac troponin I, N-terminal pro-B-type natriuretic peptide, and creatine kinase-MB; and cardiac complications were associated with increased risk of death for patients with SARS-CoV-2 infection. The confirmation that underlying cardiovascular conditions, elevation of myocardial injury biomarkers during COVID-19 infection, and acute cardiovascular decompensation are predictors for mortality in SARS-CoV-2 infection must encourage new research to clarify potential mechanisms and test appropriate treatments. (Arq Bras Cardiol. 2020; 115(2):273-277).
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="">doi:10.36660/abc.20200372</a> <a target="_blank" rel="external noopener" href="">pmid:32876196</a> <a target="_blank" rel="external noopener" href="">pmcid:PMC8384270</a> <a target="_blank" rel="external noopener" href="">fatcat:c3d54cjcibamraqfhwjq5hctmy</a> </span>
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