This study focuses on the treatment of Glaucoma with objectives overcomes certain disadvantages of Eye drops like the frequency of administration, drainage of medication by tear fluid, and greater therapeutic efficacy of drug (Brimonidine Tartrate) using ophthalmic films. The ophthalmic films of Brimonidine Tartrate were designed by solvent casting method containing PVA and PVP-k30 in different ratios as film formers, 20% v/v of PEG400 was added as plasticizer to 10 ml of distilled water. Films

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... were evaluated for physicochemical characteristics such as folding endurance, drug content, thickness, pH of the surface, moisture absorption, moisture loss, and in vitro drug release. The drug release rates the prepared formulas didn't take more than 4 hrs, the prepared formulas had acceptable physical properties. Increasing the ratios of used polymers prolonged the time of drug release from the matrix. Formula C6 which had the biggest ratio of polymers showed a controlled release within 4 hrs, however, formula C1 showed the least time of drug release in 1 hour. The drug release from most of the formulations was according to zero order pattern with n value in the range (0.5-1) indicating that drug release from matrices was mainly happened by swallowing and diffusion (non-Fickian pattern). Formula A6 by comparison with the rest of the prepared formulas showed slow release during 4 hrs