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A Role for Mitogen-activated Protein KinaseErk1/2Activation and Non-selective Pore Formation in P2X7 Receptor-mediated Thymocyte Death
Journal of Biological Chemistry
2005) . A role for mitogen-activated protein kinase (Erk1/2) activation and non-selective pore formation in P2X7 receptor-mediated thymocyte death. Extracellular ATP (ATPe) binds to P2X7 receptors (P2X7R) expressed on the surface of cells of hematopoietic lineage, including murine thymocytes. Activation of P2X7R by ATPe results in the opening of cation-specific channels, and prolonged ATPe exposure leads to the formation of non-selective pores enabling transmembrane passage of solutes up to 900doi:10.1074/jbc.m501290200 pmid:15937334 fatcat:cecjluaukrgjhd4s6ktfey2sie