Biomolecules such as protein, peptide and nucleic acids interact with each other in the cell controlling its life activities. Therefore, techniques to reproduce biomolecular interactions correctly on the solid substrate would be a good versatile way to clarify the biological phenomena. In this research, we investigated the influence of protein orientation and density on peptide-protein interaction (adopting cysteine synthase (CS) complex formation as the model) detection with employing site

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... ific protein immobilization technique. As the results, consideration of the location of functional site with avoiding the steric hindrance by adjusting the protein density and the degree of freedom of the peptide would be important to design higher interaction detection system. 2P086 無機基板表面を標的としたラクダ抗体から着想するスマート なバイオセンサー仕様抗体の設計