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An epithelial target site in experimental graft-versus-host disease and cytokine-mediated cytotoxicity is defined by cytokeratin 15 expression
Biology of Blood and Marrow Transplantation
The identity of cells within squamous epithelia that represent primary targets in acute graft-versus-host disease (GVHD) has been an enigma. Murine effector T cells implicated in the alloresponse by V␤ complementarity-determining region-3 spectratype analysis were detected with a V␤-specific monoclonal antibody within discrete microdomains of tongue (lingual) squamous epithelium. These microdomains, termed rete-like prominences (RLPs), are similar to the rete ridges of human skin. Cells formingdoi:10.1016/s1083-8791(03)00288-x pmid:14506658 fatcat:wsrv7ixldndw7kezjcl6lsddf4