Synthesis and Antimicrobial Activity of 2-Amino-4-(substitutedphenyl)-6-{4-[3-chloro-2-(4-chlorophenyl)-4-oxoazetidin -1-yl] phenyl}pyridine-3-carbonitrile

2015 Chemical Science Transactions  
Pyridine the simplest and perhaps is the best-known heterocyclic compound. The credit for the discovery of pyridine goes to Anderson who first obtained it from bone oil. The simple pyridine compounds are prepared by the cyclization of aliphatic raw materials. A new series of 2-amino-4-(substitutedphenyl)-6-{4-[3-chloro-2-(4-chlorophenyl)-4-oxoazetidin-1-yl] phenyl} pyridine-3carbonitrile are synthesized by reacting 3-chloro-1-{4-[5-(substituted
more » ... ]phenyl}-4-(4-chlorophenyl)azetidin-2-one with malanonitrile and ammonium acetate by using ethanol as a solvent. All these compounds were characterized by means of their IR, 1 H NMR, Spectroscopic data and microanalysis. All the compounds were tested for their antibacterial and antifungal activities by broth dilution method.
doi:10.7598/cst2015.1072 fatcat:ergvtrx2obegpnmuztlotqigsa