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Smooth Muscle Cells and Myofibroblasts Use Distinct Transcriptional Mechanisms for Smooth Muscle -Actin Expression
2007
Circulation Research
There has been considerable controversy regarding the lineage relationship between smooth muscle cells (SMCs) and myofibroblasts, because they express a number of common cell-selective markers including smooth muscle (SM) ␣-actin. We have shown previously that MCAT elements within the SM ␣-actin promoter confer differential activity in cultured SMCs versus myofibroblasts. In the present study, to determine the role of MCAT elements in vivo, we generated transgenic mice harboring an SM ␣-actin
doi:10.1161/circresaha.107.154831
pmid:17823374
fatcat:l6rskr24vvfbbfkbdbxleideuy