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Crystal structure of the DENR-MCT-1 complex
The density-regulated protein (DENR) and the malignant T cellamplified sequence 1 (MCT-1/MCTS1) oncoprotein support noncanonical translation initiation, promote translation reinitiation on a specific set of mRNAs with short upstream reading frames, and regulate ribosome recycling. DENR and MCT-1 form a heterodimer, which binds to the ribosome. We determined the crystal structure of the heterodimer formed by human MCT-1 and the N-terminal domain of DENR at 2.0-Å resolution. The structure of thedoi:10.2210/pdb6ms4/pdb fatcat:ykbyb4tcuffelerzt2gtxsjlcu