A Rare Cause of Refractory Chronic Diarrhea and Cachexia: A Case Report

Faten HADJ KACEM, Donia CHEBBI, Amal CHAKROUN, Nadia CHARFI, Dorra GHORBEL, Fatma MNIF, Mouna MNIF, Nabila REKIK, Mohamed ABID
2020 Iranian Journal of Public Health  
VIPoma is an unusual neuroendocrine neoplasm that autonomously secretes VIP. It is associated with secretory diarrhea and electrolyte disturbances. Herein we report a case of a male patient, who was hospitalized in the Department of Endocrinology in Hedi Chaker Hospital, Sfax, Tunisia. He presented VIPoma syndrome, with hepatic metastases at diagnosis. He had a history of chronic, watery diarrhea. He was dehydrated with many electrolytic disorders as hypokalemia, hyponatremia and metabolic
more » ... sis. Abdominal CT scan showed a heterogeneous mass in the pancreatic head with multiple hepatic lesions. A high VIP hormone level was found. Histological study of a liver biopsy revealed hepatic metastases of neuroendocrine carcinoma. The patient received analogues of somatostatin and systemic chemotherapy, with a transient symptomatic relief. Sadly the patient was lost to follow-up.
doi:10.18502/ijph.v49i2.3110 fatcat:c73536yixfbrplcdyaadeh3zla