Is Pethidine Safe during Labor? Systematic Review

Rogevando Nunes, Paulo Colares, Juliana Montenegro
2017 Revista Brasileira de Ginecologia e Obstetrícia  
Purpose To verify if pethidine is safe for the conceptus when used during labor. Methods Systematic review in the Capes Periodicals/PubMed and MEDLINE/Virtual Health Library (BVS, in the Portuguese acronym) databases. Results A total of 17 studies published from January 1st, 2000, to September 2nd, 2016, with a total of 1,688 participants involved were included in the present review. There was no record of conceptus vitality decrease associated with low doses of pethidine being administered to
more » ... others during labor. Conclusions Intramuscular (IM) or intravenous (IV) pethidine at low doses, of up to 50 mg, is safe to administer during labor.
doi:10.1055/s-0037-1604065 pmid:28666300 fatcat:mx5s2aqrcrceng7mqo5r5n2dnu