Ultrarapid, Convection-Enhanced Intravascular Hypothermia: A Feasibility Study in Nonhuman Primate Stroke

W. J. Mack, J. Huang, C. Winfree, G. Kim, M. Oppermann, J. Dobak, B. Inderbitzen, S. Yon, S. Popilskis, J. Lasheras, R. R. Sciacca, D. J. Pinsky (+1 others)
2003 Stroke  
and Purpose-Hypothermia has been shown to be neuroprotective in a variety of clinical settings. Unfortunately, poor delivery techniques and insufficient data in appropriate preclinical models have hampered its development in human stroke. To address these limitations, we have devised a 10F intravascular catheter capable of rapid systemic cooling of nonhuman primates. Methods-Placed in the inferior vena cava via a transfemoral approach, the catheter was used to induce mild systemic hypothermia 3
more » ... temic hypothermia 3 hours after the onset of hemispheric stroke in baboons. Results-Cooling was achieved at a rate of 6.3Ϯ0.8°C/h. Target brain temperatures (32.2Ϯ0.2°C) were reached at the same time (47.7Ϯ6.32 minutes) as target esophageal temperatures (32.0Ϯ0.0°C). Hypothermia was maintained for 6 hours in all animals. Animals did not experience the infections, coagulopathy, or cerebral edema commonly seen with surface cooling methods in human stroke. Conclusions-These data suggest that a brief episode of mild core hypothermia instituted at a clinically relevant time point can be achieved in primate stroke and that our intravascular cooling technique provides safe, rapid, and reproducible hypothermia. (Stroke. 2003;34:1994-1999
doi:10.1161/01.str.0000079813.31539.6d pmid:12829868 fatcat:zylunenpm5gl7mqhanpjrt6ic4