Abstract 23

Joseph Catapano, Kasra Tajdaran, Jennifer J. Zhang, Tessa Gordon, Gregory H. Borschel
2018 Plastic and Reconstructive Surgery, Global Open  
PSRC Abstract Supplement with corneal neurotization (30.1 % ± 12.7 vs. 0.0 % ± 0.0, p < 0.001). All rats without corneal neurotization treatment developed progressive corneal epithelial breakdown, while only one rat with corneal neurotization developed a corneal ulceration that healed within one week (p = 0.047). Eighty percent of rats without corneal neurotization developed a corneal perforation after tarsorrhaphy removal, in comparison to no rats with corneal neurotization (p = 0.008).
more » ... (p = 0.008). Corneal neurotization treatment also significantly decreased corneal scarring. contains representative images demonstrating significant corneal scarring, perforation (A) and ulceration (B) in a rat without corneal neurotization seven days after tarsorrhaphy removal and improved ocular surface health in a rat treated with corneal neurotization (C/D). CONCLUSION: Corneal neurotization decreases breakdown of the corneal epithelium in rats with NK and prevents perforation and scarring. This data demonstrates that axons reinnervating the cornea improve corneal epithelial maintenance and repair, although further research using this model is required to investigate the underlying mechanism. These findings support clinical studies showing that corneal neurotization improves ocular surface health and preserves vision in patients with NK.
doi:10.1097/01.gox.0000533888.36841.96 fatcat:fgfqz57ovfdpzh2xhdezrecr4u