Limited and Strain-Specific Transcriptional and Growth Responses to Acquisition of a Multidrug Resistance Plasmid in Genetically Diverse Escherichia coli Lineages

Steven Dunn, Laura Carrilero, Michael Brockhurst, Alan McNally, David W. Cleary
2021 mSystems  
Plasmids play a key role in bacterial evolution by transferring adaptive functions between lineages that often enable invasion of new niches, including driving the spread of antibiotic resistance genes. Fitness costs of plasmid acquisition arising from the disruption of cellular processes could limit the spread of multidrug resistance plasmids.
doi:10.1128/msystems.00083-21 fatcat:xveypekd6vdhdn7mmvsb3gp4pq