Oral cancer is one of the most widespread tumors of the head and neck region. An earlier diagnosis can help dentist getting a better therapy plan, giving patients a better treatment and the reliable techniques for detecting oral cancer cells are urgently required. This study proposes an optic and automation method using reflection images obtained with scanned laser pico-projection system, and Gray-Level Co-occurrence Matrix for sampling. Moreover, the artificial intelligence technology, Support

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... Vector Machine, was used to classify samples. Normal Oral Keratinocyte and dysplastic oral keratinocyte were simulating the evolvement of cancer to be classified. The accuracy in distinguishing two cells has reached 85.22%. Compared to existing diagnosis methods, the proposed method possesses many advantages, including a lower cost, a larger sample size, an instant, a non-invasive, and a more reliable diagnostic performance. As a result, it provides a highly promising solution for the early diagnosis of oral squamous carcinoma.