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Mitochondrial RNA capping: highly efficient 5'-RNA capping with NAD+and NADH by yeast and human mitochondrial RNA polymerase
Bacterial and eukaryotic nuclear RNA polymerases (RNAPs) cap RNA with the oxidized and reduced forms of the metabolic effector nicotinamide adenine dinucleotide, NAD+and NADH, using NAD+and NADH as non canonical initiating nucleotides for transcription initiation. Here, we show that mitochondrial RNAPs (mtRNAPs) cap RNA with NAD+and NADH, and do so more efficiently than nuclear RNAPs. Direct quantitation of NAD+- and NADH-capped RNA demonstrates remarkably high levels of capping in vivo: up todoi:10.1101/381160 fatcat:ck3mnjdmvvfqjimqcfuc5zsku4