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The mineralocorticoid receptor (MR), a member of the steroid hormone receptor family, acts as an inducible transcription factor and plays an important role in water- and salt homeostasis. Additionally the activated MR induces pathophysiological changes in cardiovascular system like endothelial dysfunction, vascular remodeling and heart failure. Besides controlling gene expression (genomic MR effect), the activated MR is able to interfere with cytosolic signaling pathways (non-genomic effect) bydoi:10.25673/958 fatcat:ooz5e6skvjclhp7oajuxajdyjq