The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

Werner E. G. Müller, Meik Neufurth, Hadrian Schepler, Shunfeng Wang, Emad Tolba, Heinz C. Schröder, Xiaohong Wang
2020 Biomaterials Science  
The polymer polyphosphate, abundant in blood platelets, blocks the binding of the receptor-binding domain (RBD) of the SARS- spike (S)-protein to the angiotensin-converting enzyme 2 (ACE2) at low concentrations.
doi:10.1039/d0bm01244k pmid:33231598 fatcat:kclz5m7ddfa4papifbto3j75ne