Memory impairments associated with hippocampal versus parahippocampal-gyrus atrophy: an MR volumetry study in Alzheimer's disease

S. Köhler, S.E. Black, M. Sinden, C. Szekely, D. Kidron, J.L. Parker, J.K. Foster, M. Moscovitch, G. Wincour, J.P. Szalai, M.J. Bronskill
1998 Neuropsychologia  
Delayed memory impairments and medial temporal!lobe atrophy are considered to be cardinal features of Alzheimer|s disease "AD#[ The goal of the present magnetic resonance "MR# volumetry study was to investigate the relationship between both features[ We determined MR!derived estimates of hippocampal and parahippocampal volume in a sample of 16 AD patients and in a group of 15 healthy control subjects "NCs# of comparable age and education[ We examined the performance of the two groups on
more » ... e and delayed recall trials of an auditoryÐverbal list!learning task "CVLT#\ a visual non!verbal memory task "Visual Reproduction of the WMS!R#\ and a screening procedure that provides an estimate of overall cognitive functioning "DRS#[ Volumes of the hippocampus and the parahippocampal gyrus were signi_cantly smaller in AD patients than in NCs[ AD patients were impaired in their overall level of cognitive functioning and showed memory de_cits under immediate and delayed recall conditions[ The association between medial temporal!lobe atrophy and cognitive impairments in AD was found to be highly speci_c] Hippo! campal volume correlated positively with delayed but not immediate recall of the verbalÐauditory list learning task[ In contrast\ parahippocampal gyrus volume\ speci_cally in the right hemisphere\ was positively related to delayed but not immediate recall of the non!verbal visual memory task[ In NCs\ there was a trend towards a negative association between hippocampal volumes and delayed verbal recall[ Our results suggest that hippocampal and parahippocampal gyrus atrophy in AD are related to distinct aspects of the patients| memory impairments[ Our _ndings have implications for current discussions regarding contributions of the hippocampus and the parahippocampal gyrus to memory in the intact human brain[ Þ 0887 Elsevier Science Ltd[ All rights reserved[ Key Words] anterograde amnesia^hippocampus^medial temporal lobes^human^episodic memory^magnetic resonance[
doi:10.1016/s0028-3932(98)00017-7 pmid:9740363 fatcat:n5kdkye3bjd6fmd4ev4rqhybzy