Ontogeny of Langerin/CD207 Expression in the Epidermis of Mice

Christoph H. Tripp, Souyet Chang-Rodriguez, Patrizia Stoitzner, Sandra Holzmann, Hella Stössel, Patrice Douillard, Sem Saeland, Franz Koch, Adelheid Elbe-Bürger, Nikolaus Romani
2004 Journal of Investigative Dermatology  
C-type lectin receptors help Langerhans cells (LC) to take up and process pathogens. Langerin/CD207 is a mannose-binding C-type lectin that is specifically expressed by LC. It is involved in antigen uptake in an as yet poorly defined way, and it is a major molecular constituent of Birbeck granules. We studied the emergence of Langerin expression in LC in epidermal sheets and cell suspensions during ontogeny. Langerin appears later than MHC II expression. Intracellular Langerin expression
more » ... apparent 2-3 d after birth. Only 10 days after birth all LC co-express Langerin. The intensity of Langerin expression reaches adult levels by 3 wk after birth. Early Langerin expression appears to correlate at least in part with the physical presence of Birbeck granules.
doi:10.1111/j.0022-202x.2004.22337.x pmid:15086552 fatcat:j74gm5kwerd4vae4x7laqcf6vu