Semantic Subgroup Discovery and Cross-Context Linking for Microarray Data Analysis [chapter]

Igor Mozetič, Nada Lavrač, Vid Podpečan, Petra Kralj Novak, Helena Motaln, Marko Petek, Kristina Gruden, Hannu Toivonen, Kimmo Kulovesi
2012 Lecture Notes in Computer Science  
The article presents an approach to computational knowledge discovery through the mechanism of bisociation. Bisociative reasoning is at the heart of creative, accidental discovery (e.g., serendipity), and is focused on finding unexpected links by crossing contexts. Contextualization and linking between highly diverse and distributed data and knowledge sources is therefore crucial for the implementation of bisociative reasoning. In the article we explore these ideas on the problem of analysis of
more » ... microarray data. We show how enriched gene sets are found by using ontology information as background knowledge in semantic subgroup discovery. These genes are then contextualized by the computation of probabilistic links to diverse bioinformatics resources. Preliminary experiments with microarray data illustrate the approach.
doi:10.1007/978-3-642-31830-6_27 fatcat:ros55glzj5aktly7fzyycdnf7u